Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00PNU
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| Former ID |
DIB013284
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| Drug Name |
TGN-1412
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| Synonyms |
SuperMAB; CD28-SuperMAB; Superagonistic monoclonal antibodies, TeGenero
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| Drug Type |
Antibody
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| Indication | Autoimmune diabetes [ICD-11: 5A10] | Discontinued in Phase 1 | [1] | |
| Company |
TeGenero ImmunoTherapeutics AG
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | T-cell-specific surface glycoprotein CD28 (CD28) | Target Info | . | [2] |
| KEGG Pathway | Cell adhesion molecules (CAMs) | |||
| T cell receptor signaling pathway | ||||
| Intestinal immune network for IgA production | ||||
| Type I diabetes mellitus | ||||
| Measles | ||||
| Autoimmune thyroid disease | ||||
| Systemic lupus erythematosus | ||||
| Rheumatoid arthritis | ||||
| Allograft rejection | ||||
| Graft-versus-host disease | ||||
| Viral myocarditis | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | T cell activation | |||
| Pathway Interaction Database | TCR signaling in naï | |||
| TCR signaling in naï | ||||
| IL12 signaling mediated by STAT4 | ||||
| Reactome | PIP3 activates AKT signaling | |||
| Constitutive Signaling by Aberrant PI3K in Cancer | ||||
| CD28 co-stimulation | ||||
| CD28 dependent PI3K/Akt signaling | ||||
| CD28 dependent Vav1 pathway | ||||
| WikiPathways | TCR Signaling Pathway | |||
| Inflammatory Response Pathway | ||||
| Host Interactions of HIV factors | ||||
| PIP3 activates AKT signaling | ||||
| T-Cell Receptor and Co-stimulatory Signaling | ||||
| Allograft Rejection | ||||
| Costimulation by the CD28 family | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020365) | |||
| REF 2 | TGN1412: From Discovery to Disaster. J Young Pharm. 2010 Jul-Sep; 2(3): 332-336. | |||
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