Drug Information
Drug General Information | Top | |||
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Drug ID |
D00NIT
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Former ID |
DIB021244
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Drug Name |
YM 471
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Synonyms |
YM-471
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C39H38F2N4O3
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Canonical SMILES |
CN(C)C1CCN(CC1)C(=O)C=C2C3=CC=CC=C3N(CCC2(F)F)C(=O)C4=CC=C(C=C4)NC(=O)C5=CC=CC=C5C6=CC=CC=C6
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InChI |
1S/C39H38F2N4O3/c1-43(2)30-20-23-44(24-21-30)36(46)26-34-33-14-8-9-15-35(33)45(25-22-39(34,40)41)38(48)28-16-18-29(19-17-28)42-37(47)32-13-7-6-12-31(32)27-10-4-3-5-11-27/h3-19,26,30H,20-25H2,1-2H3,(H,42,47)/b34-26-
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InChIKey |
ICRPTZMWRJGNQI-CLIDGEQKSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Vasopressin V1a receptor (V1AR) | Target Info | Antagonist | [2] |
Vasopressin V1b receptor (V1BR) | Target Info | Antagonist | [2] | |
Vasopressin V2 receptor (V2R) | Target Info | Antagonist | [2] | |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Vascular smooth muscle contraction | ||||
Vasopressin-regulated water reabsorption | ||||
Pathwhiz Pathway | Vasopressin Regulation of Water Homeostasis | |||
Pathway Interaction Database | Arf6 trafficking events | |||
Reactome | Vasopressin-like receptors | |||
G alpha (q) signalling events | ||||
G alpha (s) signalling events | ||||
Vasopressin regulates renal water homeostasis via Aquaporins | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
Regulation of Water Balance by Renal Aquaporins |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2205). | |||
REF 2 | Effects of YM471, a nonpeptide AVP V(1A) and V(2) receptor antagonist, on human AVP receptor subtypes expressed in CHO cells and oxytocin receptors in human uterine smooth muscle cells. Br J Pharmacol. 2001 Jul;133(5):746-54. |
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