Drug Information
Drug General Information | Top | |||
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Drug ID |
D00MLQ
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Former ID |
DIB013699
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Drug Name |
Protosufloxacin
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Synonyms |
A-71497
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Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Terminated | [1] | |
Company |
Abbott Laboratories
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Structure |
Download2D MOL |
Interaction between the Drug and Microbe | Top | |||
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The Abundace of Studied Microbe(s) Regulated by Drug | ||||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
Studied Microbe: Bacteroides caccae
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Bacteroides caccae was decreased by Tosufloxacin hydrochloride (adjusted p-values: 5.04E-06). | |||
Studied Microbe: Bacteroides fragilis enterotoxigenic
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Bacteroides fragilis enterotoxigenic was decreased by Tosufloxacin hydrochloride (adjusted p-values: 5.85E-06). | |||
Studied Microbe: Bacteroides fragilis nontoxigenic
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Bacteroides fragilis nontoxigenic was decreased by Tosufloxacin hydrochloride (adjusted p-values: 6.71E-06). | |||
Studied Microbe: Bacteroides ovatus
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Bacteroides ovatus was decreased by Tosufloxacin hydrochloride (adjusted p-values: 5.04E-06). | |||
Studied Microbe: Bacteroides thetaiotaomicron
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Bacteroides thetaiotaomicron was decreased by Tosufloxacin hydrochloride (adjusted p-values: 1.10E-05). | |||
Studied Microbe: Bacteroides uniformis
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Bacteroides uniformis was decreased by Tosufloxacin hydrochloride (adjusted p-values: 6.45E-07). | |||
Studied Microbe: Bacteroides vulgatus
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Bacteroides vulgatus was decreased by Tosufloxacin hydrochloride (adjusted p-values: 1.95E-06). | |||
Studied Microbe: Bacteroides xylanisolvens
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Bacteroides xylanisolvens was decreased by Tosufloxacin hydrochloride (adjusted p-values: 4.93E-07). | |||
Studied Microbe: Odoribacter splanchnicus
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Odoribacter splanchnicus was decreased by Tosufloxacin hydrochloride (adjusted p-values: 5.04E-06). | |||
Studied Microbe: Parabacteroides distasonis
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Parabacteroides distasonis was decreased by Tosufloxacin hydrochloride (adjusted p-values: 2.74E-07). | |||
Studied Microbe: Parabacteroides merdae
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Parabacteroides merdae was decreased by Tosufloxacin hydrochloride (adjusted p-values: 5.04E-06). | |||
Studied Microbe: Prevotella copri
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Prevotella copri was decreased by Tosufloxacin hydrochloride (adjusted p-values: 3.40E-05). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
Studied Microbe: Bifidobacterium adolescentis
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Bifidobacterium adolescentis was decreased by Tosufloxacin hydrochloride (adjusted p-values: 5.04E-06). | |||
Studied Microbe: Bifidobacterium longum
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Bifidobacterium longum was decreased by Tosufloxacin hydrochloride (adjusted p-values: 5.04E-06). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
Studied Microbe: Collinsella aerofaciens
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Collinsella aerofaciens was decreased by Tosufloxacin hydrochloride (adjusted p-values: 2.73E-07). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
Studied Microbe: Eggerthella lenta
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Eggerthella lenta was decreased by Tosufloxacin hydrochloride (adjusted p-values: 9.91E-06). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
Studied Microbe: Escherichia coli ED1a
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Escherichia coli ED1a was decreased by Tosufloxacin hydrochloride (adjusted p-values: 5.20E-06). | |||
Studied Microbe: Escherichia coli IAI1
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Escherichia coli IAI1 was decreased by Tosufloxacin hydrochloride (adjusted p-values: 4.93E-07). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
Studied Microbe: Erysipelatoclostridium ramosum
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Erysipelatoclostridium ramosum was decreased by Tosufloxacin hydrochloride (adjusted p-values: 9.56E-06). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
Studied Microbe: Blautia obeum
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Blautia obeum was decreased by Tosufloxacin hydrochloride (adjusted p-values: 1.95E-06). | |||
Studied Microbe: Clostridioides difficile
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Clostridioides difficile was decreased by Tosufloxacin hydrochloride (adjusted p-values: 5.07E-06). | |||
Studied Microbe: Clostridium perfringens
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Clostridium perfringens was decreased by Tosufloxacin hydrochloride (adjusted p-values: 5.51E-07). | |||
Studied Microbe: Coprococcus comes
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Coprococcus comes was decreased by Tosufloxacin hydrochloride (adjusted p-values: 5.04E-06). | |||
Studied Microbe: Dorea formicigenerans
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Dorea formicigenerans was decreased by Tosufloxacin hydrochloride (adjusted p-values: 5.08E-06). | |||
Studied Microbe: Enterocloster bolteae
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Enterocloster bolteae was decreased by Tosufloxacin hydrochloride (adjusted p-values: 2.41E-05). | |||
Studied Microbe: Eubacterium eligens
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Eubacterium eligens was decreased by Tosufloxacin hydrochloride (adjusted p-values: 1.77E-05). | |||
Studied Microbe: Eubacterium rectale
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Eubacterium rectale was decreased by Tosufloxacin hydrochloride (adjusted p-values: 3.06E-04). | |||
Studied Microbe: Lacrimispora saccharolytica
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Lacrimispora saccharolytica was decreased by Tosufloxacin hydrochloride (adjusted p-values: 5.51E-07). | |||
Studied Microbe: Roseburia hominis
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Roseburia hominis was decreased by Tosufloxacin hydrochloride (adjusted p-values: 2.07E-05). | |||
Studied Microbe: Roseburia intestinalis
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Roseburia intestinalis was decreased by Tosufloxacin hydrochloride (adjusted p-values: 1.65E-04). | |||
Studied Microbe: Ruminococcus bromii
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Ruminococcus bromii was decreased by Tosufloxacin hydrochloride (adjusted p-values: 1.36E-05). | |||
Studied Microbe: Ruminococcus gnavus
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Ruminococcus gnavus was decreased by Tosufloxacin hydrochloride (adjusted p-values: 1.86E-05). | |||
Studied Microbe: Ruminococcus torques
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Ruminococcus torques was decreased by Tosufloxacin hydrochloride (adjusted p-values: 6.84E-07). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
Studied Microbe: Lactobacillus paracasei
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Lactobacillus paracasei was decreased by Tosufloxacin hydrochloride (adjusted p-values: 5.51E-07). | |||
Studied Microbe: Streptococcus parasanguinis
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Streptococcus parasanguinis was decreased by Tosufloxacin hydrochloride (adjusted p-values: 5.51E-07). | |||
Studied Microbe: Streptococcus salivarius
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Streptococcus salivarius was decreased by Tosufloxacin hydrochloride (adjusted p-values: 1.67E-06). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Veillonellales | ||||
Studied Microbe: Veillonella parvula
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Veillonella parvula was decreased by Tosufloxacin hydrochloride (adjusted p-values: 5.04E-06). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
Studied Microbe: Akkermansia muciniphila
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Akkermansia muciniphila was decreased by Tosufloxacin hydrochloride (adjusted p-values: 6.83E-04). |
Target and Pathway | Top | |||
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Target(s) | Bacterial DNA gyrase (Bact gyrase) | Target Info | Modulator | [3] |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003745) | |||
REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. |
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