Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00LVA
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| Former ID |
DPR000036
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| Drug Name |
Dianicline
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| Synonyms |
SSR591813; SSR591813L; 5a,6,9,10-Tetrahydro-7H,11H-8,10a-methanopyrido(2',3'-5,6)pyrano(2,3-d)azepine
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| Drug Type |
Small molecular drug
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| Indication | Tobacco dependence [ICD-11: 6C4A.2; ICD-10: F17.2; ICD-9: 305.1] | Discontinued in Phase 3 | [1] | |
| Company |
Sanofi-Aventis
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| Structure |
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Download2D MOL |
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| Formula |
C13H16N2O
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| Canonical SMILES |
C1CN2CCC3(C2)C1OC4=C(C3)N=CC=C4
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| InChI |
1S/C13H16N2O/c1-2-11-10(14-5-1)8-13-4-7-15(9-13)6-3-12(13)16-11/h1-2,5,12H,3-4,6-9H2/t12-,13+/m0/s1
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| InChIKey |
SUPRUPHAEXPGPF-QWHCGFSZSA-N
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| CAS Number |
CAS 292634-27-6
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| SuperDrug ATC ID |
J01GB10
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| SuperDrug CAS ID |
cas=025546650
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Emerging drugs for the treatment of tobacco dependence. Expert Opin Emerg Drugs. 2009 Mar;14(1):23-32. | |||
| REF 2 | Dianicline, a novel 42 nicotinic acetylcholine receptor partial agonist, for smoking cessation: a randomized placebo-controlled clinical trial.Nicotine Tob Res.2011 Jan;13(1):1-6. | |||
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