Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00KGL
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| Drug Name |
PMID27998201-Compound-8
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| Drug Type |
Small molecular drug
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| Company |
F. HOFFMANN-LA ROCHE AG BANNER, David CECCARELLI, Simona M. GRETHER, Uwe HAAP, Wolfgang HILPERT, Hans KUEHNE, Holger MAUSER, Harald PLANCHER, Jean-Marc SANCHEZ, Rub Alvare
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| Structure |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cathepsin K (CTSK) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Cathepsin K (CTSK) | Target's Patent Info | [1] | |
| KEGG Pathway | Lysosome | |||
| Osteoclast differentiation | ||||
| Toll-like receptor signaling pathway | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| RANKL Signaling Pathway | ||||
| IL2 Signaling Pathway | ||||
| Reactome | Collagen degradation | |||
| Degradation of the extracellular matrix | ||||
| Activation of Matrix Metalloproteinases | ||||
| Trafficking and processing of endosomal TLR | ||||
| MHC class II antigen presentation | ||||
| WikiPathways | RANKL/RANK Signaling Pathway | |||
| Osteoclast Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. | |||
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