Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00JHN
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| Former ID |
DIB020647
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| Drug Name |
PBD150
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| Synonyms |
compound 53 [PMID 16420052]
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C15H20N4O2S
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| Canonical SMILES |
COC1=C(C=C(C=C1)NC(=S)NCCCN2C=CN=C2)OC
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| InChI |
1S/C15H20N4O2S/c1-20-13-5-4-12(10-14(13)21-2)18-15(22)17-6-3-8-19-9-7-16-11-19/h4-5,7,9-11H,3,6,8H2,1-2H3,(H2,17,18,22)
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| InChIKey |
FZQXMGLQANXZRP-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID |
11108680, 11645013, 16402380, 43184413, 51042801, 103477290, 104179578, 104179584, 104179586, 114615179, 125003866, 137274746, 137439846, 144072323, 144072327, 144072331, 144072343, 144072345, 144072346, 144072349, 170483656, 170483659, 170484999, 170485000, 170485001, 170485002, 173332281, 173332282, 226456199, 248767666, 252155789, 252166568
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glutaminyl cyclase (QPCT) | Target Info | Inhibitor | [2] |
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta. Biochemistry. 2008 Jul 15;47(28):7405-13. | |||
| REF 2 | The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship. J Med Chem. 2006 Jan 26;49(2):664-77. | |||
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