Drug Information
Drug General Information | Top | |||
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Drug ID |
D00IKR
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Drug Name |
US8536181, A41
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Synonyms |
SCHEMBL1770480; CHEMBL3115298; UPJZLOCUUOIMNC-UHFFFAOYSA-N; BDBM102348; US8536181, A41; tert-butyl 4-((1-(4-chlorobenzyl)-3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl)methyl)piperazine-1-carboxylate
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Drug Type |
Small molecular drug
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Structure |
Download2D MOL |
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Formula |
C22H28ClN3O4
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Canonical SMILES |
CC(C)(C)OC(=O)N1CCN(CC1)CC2=C(C(=O)N(C=C2)CC3=CC=C(C=C3)Cl)O
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InChI |
1S/C22H28ClN3O4/c1-22(2,3)30-21(29)25-12-10-24(11-13-25)15-17-8-9-26(20(28)19(17)27)14-16-4-6-18(23)7-5-16/h4-9,27H,10-15H2,1-3H3
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InChIKey |
UPJZLOCUUOIMNC-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | HIF-prolyl hydroxylase 2 (HPH-2) | Target Info | Inhibitor | [1] |
Target's Patent Info | HIF-prolyl hydroxylase 2 (HPH-2) | Target's Patent Info | [1] | |
KEGG Pathway | HIF-1 signaling pathway | |||
Pathways in cancer | ||||
Renal cell carcinoma | ||||
Panther Pathway | Hypoxia response via HIF activation | |||
Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | ||||
HIF-1-alpha transcription factor network | ||||
Reactome | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
References | Top | |||
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REF 1 | Prolyl hydroxylase inhibitors. US8536181. |
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