Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D00HXZ
|
|||
Former ID |
DNC005976
|
|||
Drug Name |
2-morpholino-6-(thianthren-1-yl)-4H-chromen-4-one
|
|||
Synonyms |
CHEMBL200824
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
|||
Formula |
C25H19NO3S2
|
|||
Canonical SMILES |
C1COCCN1C2=CC(=O)C3=C(O2)C=CC(=C3)C4=C5C(=CC=C4)SC6=CC=CC=C6S5
|
|||
InChI |
1S/C25H19NO3S2/c27-19-15-24(26-10-12-28-13-11-26)29-20-9-8-16(14-18(19)20)17-4-3-7-23-25(17)31-22-6-2-1-5-21(22)30-23/h1-9,14-15H,10-13H2
|
|||
InChIKey |
NXGBJPCXFKHQKN-UHFFFAOYSA-N
|
|||
PubChem Compound ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | DNA-dependent protein kinase catalytic (PRKDC) | Target Info | Inhibitor | [1] |
KEGG Pathway | Non-homologous end-joining | |||
Cell cycle | ||||
NetPath Pathway | IL1 Signaling Pathway | |||
Pathway Interaction Database | DNA-PK pathway in nonhomologous end joining | |||
Coregulation of Androgen receptor activity | ||||
Class I PI3K signaling events mediated by Akt | ||||
BARD1 signaling events | ||||
Reactome | Nonhomologous End-Joining (NHEJ) | |||
WikiPathways | DNA Damage Response | |||
Non-homologous end joining | ||||
FAS pathway and Stress induction of HSP regulation | ||||
Cytosolic sensors of pathogen-associated DNA | ||||
Retinoblastoma (RB) in Cancer | ||||
Prostate Cancer | ||||
Double-Strand Break Repair | ||||
Cell Cycle | ||||
miRNA Regulation of DNA Damage Response |
References | Top | |||
---|---|---|---|---|
REF 1 | Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.