Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00HSJ
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| Former ID |
DIB020725
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| Drug Name |
PIK-75
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| Synonyms |
PIK75; PIK 75; imidazopyridine derivative 8c [PMID 17601739]
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C16H14BrN5O4S
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| Canonical SMILES |
CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)N=CC2=CN=C3N2C=C(C=C3)Br
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| InChI |
1S/C16H14BrN5O4S/c1-11-3-5-13(22(23)24)7-15(11)27(25,26)20(2)19-9-14-8-18-16-6-4-12(17)10-21(14)16/h3-10H,1-2H3/b19-9+
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| InChIKey |
QTHCAAFKVUWAFI-DJKKODMXSA-N
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| CAS Number |
CAS 945619-31-8
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:94827
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Isoform-selective inhibition of phosphoinositide 3-kinase: identification of a new region of nonconserved amino acids critical for p110alpha inhibition. Mol Pharmacol. 2011 Oct;80(4):657-64. | |||
| REF 2 | A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47. | |||
| REF 3 | Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors. Bioorg Med Chem. 2007 Sep 1;15(17):5837-44. | |||
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