Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00HNB
|
|||
| Former ID |
DAP000564
|
|||
| Drug Name |
Clodronate
|
|||
| Synonyms |
Bonefos; Clodronsaeure; Dichloromethanediphosphonate; Dichloromethylenebisphosphonate; Methanedichlorodiphosphonate; Acide clodronique; Acido clodronico; Acidum clodronicum; Clodronic Acid; Dichloromethanediphosphonic acid; Dichloromethylene Biphosphonate; Dichloromethylene Diphosphonate; Dichloromethylidene diphosphonate; Liposomes containing clodronic acid; Methanedichlorodiphosphonic acid; Acid, Clodronic; Acid, Dichloromethanediphosphonic; Acide clodronique [INN-French]; Acido clodronico [INN-Spanish]; Acidum clodronicum [INN-Latin]; Biphosphonate, Dichloromethylene; Bonefos (TN); Clodron (TN); Diphosphonate, Dichloromethane; Diphosphonate, Dichloromethylene; Disodium, Clodronate; Loron (TN); Sodium, Clodronate; [dichloro(phosphono)methyl]phosphonic acid; Clodronic acid (USAN/INN); Clodronic acid [USAN:BAN:INN]; Dichlormethylen-bis(phosphonsaeure); Dichloromethylene-1,1-bisphosphonic acid; Dichloromethylene-1,1-diphosphonic acid; Phosphonic acid, (dichloromethylene)di-(8CI); (Dichloro-phosphono-methyl)-phosphonic acid; (Dichloromethylene)bisphosphonic acid; (Dichloromethylene)diphosphonic acid; (Lip-C); (dichloromethanediyl)bis(phosphonic acid)
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Hypercalcaemia [ICD-11: 5B91.0; ICD-9: 275.42] | Approved | [1] | |
| Therapeutic Class |
Antihypocalcemic Agents
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
CH4Cl2O6P2
|
|||
| Canonical SMILES |
C(P(=O)(O)O)(P(=O)(O)O)(Cl)Cl
|
|||
| InChI |
1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)
|
|||
| InChIKey |
ACSIXWWBWUQEHA-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 10596-23-3
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
626348, 8168534, 14774172, 29292386, 46508646, 47205854, 47276677, 47500570, 50007542, 56311820, 56459390, 57309969, 77226302, 85315811, 92308950, 103173333, 104090614, 104294639, 126411762, 127387376, 134337855, 134991121, 137006322, 141972100, 160964064, 163693515, 163852869, 164788386, 172858501, 175267351, 176484229, 177748383, 179117026, 184546035, 186024310, 225059298, 226408859, 252347510
|
|||
| ChEBI ID |
CHEBI:110423
|
|||
| ADReCS Drug ID | BADD_D00494 | |||
| SuperDrug ATC ID |
M05BA02
|
|||
| SuperDrug CAS ID |
cas=010596233
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adenine nucleotide translocator 1 (SLC25A4) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| Parkinson's disease | ||||
| Huntington's disease | ||||
| HTLV-I infection | ||||
| Pathwhiz Pathway | Mitochondrial Electron Transport Chain | |||
| Reactome | Mitochondrial protein import | |||
| Regulation of insulin secretion | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Host Interactions of HIV factors | ||||
| Synaptic Vesicle Pathway | ||||
| Integration of energy metabolism | ||||
| Electron Transport Chain | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Current and future treatments of bone metastases. Expert Opin Emerg Drugs. 2008 Dec;13(4):609-27. | |||
| REF 2 | Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite. Mol Pharmacol. 2002 May;61(5):1255-62. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.