Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00HLW
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| Former ID |
DIB021225
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| Drug Name |
WZ4003
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| Synonyms |
WZ-4003
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C25H29ClN6O3
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| Canonical SMILES |
CCC(=O)NC1=CC(=CC=C1)OC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCN(CC4)C)OC
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| InChI |
1S/C25H29ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h5-9,14-16H,4,10-13H2,1-3H3,(H,28,33)(H,27,29,30)
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| InChIKey |
SDGJBAUIGHSMRI-UHFFFAOYSA-N
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| CAS Number |
CAS 1214265-58-3
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | NUAK family SNF1-like kinase 2 (NUAK2) | Target Info | Inhibitor | [1] |
| Omphalocele kinase 1 (NUAK1) | Target Info | Inhibitor | [1] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 2014 Jan 1;457(1):215-25. | |||
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