Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00HDU
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| Former ID |
DAP000586
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| Drug Name |
Moexipril
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| Synonyms |
Moexiprilum; Uniretic; Moexipril (INN); Moexipril [INN:BAN]; Moexiprilum [INN-Latin]; Perdix (TN); Univasc (TN); (3S)-2-(N-{(1S)-1-[(ethyloxy)carbonyl]-3-phenylpropyl}-L-alanyl)-6,7-bis(methyloxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Approved | [1], [2] | |
| Therapeutic Class |
Antihypertensive Agents
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| Company |
Ucb Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C27H34N2O7
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| Canonical SMILES |
CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=CC(=C(C=C3CC2C(=O)O)OC)OC
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| InChI |
1S/C27H34N2O7/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32/h6-10,14-15,17,21-22,28H,5,11-13,16H2,1-4H3,(H,31,32)/t17-,21-,22-/m0/s1
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| InChIKey |
UWWDHYUMIORJTA-HSQYWUDLSA-N
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| CAS Number |
CAS 103775-10-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9906, 7980014, 10224695, 14884255, 14933223, 44422239, 46508441, 48416289, 50077632, 51009191, 85789110, 93166165, 96024913, 103339306, 103831006, 103984203, 104404350, 117576966, 126683035, 129432080, 134222210, 134337877, 135049415, 135153605, 137003828, 141323944, 143493279, 151982736, 152164600, 152238590, 160964036, 162178212, 164786738, 172914179, 175266162, 178103185, 179149500, 184545955, 223440353, 223653409, 224369399, 226420555, 252390154
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| ChEBI ID |
CHEBI:6960
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| ADReCS Drug ID | BADD_D01485 | |||
| SuperDrug ATC ID |
C09AA13
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| SuperDrug CAS ID |
cas=103775106
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiotensin-converting enzyme (ACE) | Target Info | Inhibitor | [3] |
| KEGG Pathway | Renin-angiotensin system | |||
| Chagas disease (American trypanosomiasis) | ||||
| Hypertrophic cardiomyopathy (HCM) | ||||
| Pathwhiz Pathway | Angiotensin Metabolism | |||
| Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
| WikiPathways | ACE Inhibitor Pathway | |||
| Metabolism of Angiotensinogen to Angiotensins | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6571). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Moexipril for treatment of primary biliary cirrhosis in patients with an incomplete response to ursodeoxycholic acid. Dig Dis Sci. 2010 Feb;55(2):476-83. | |||
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