Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00HBE
|
|||
| Former ID |
DIB014053
|
|||
| Drug Name |
AZD0914
|
|||
| Synonyms |
Zoliflodacin
Click to Show/Hide
|
|||
| Indication | Neisseria gonorrhoeae infection [ICD-11: 1A7Z; ICD-10: A54, A54.9] | Phase 3 | [1] | |
| Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Phase 2 | [2] | ||
| Company |
Astrazeneca
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C22H22FN5O7
|
|||
| Canonical SMILES |
CC1CN2C(C(O1)C)C3(CC4=CC5=C(C(=C42)F)ON=C5N6C(COC6=O)C)C(=O)NC(=O)NC3=O
|
|||
| InChI |
1S/C22H22FN5O7/c1-8-7-33-21(32)28(8)17-12-4-11-5-22(18(29)24-20(31)25-19(22)30)16-10(3)34-9(2)6-27(16)14(11)13(23)15(12)35-26-17/h4,8-10,16H,5-7H2,1-3H3,(H2,24,25,29,30,31)/t8-,9+,10-,16+/m0/s1
|
|||
| InChIKey |
ZSWMIFNWDQEXDT-ZESJGQACSA-N
|
|||
| CAS Number |
CAS 1620458-09-4
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial DNA gyrase (Bact gyrase) | Target Info | Modulator | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT03959527) Zoliflodacin in Uncomplicated Gonorrhoea. U.S. National Institutes of Health. | |||
| REF 2 | ClinicalTrials.gov (NCT02257918) Randomized, Open-label Phase 2 Study of Oral AZD0914 in the Treatment of Gonorrhea. U.S. National Institutes of Health. | |||
| REF 3 | High in vitro activity of the novel spiropyrimidinetrione AZD0914, a DNA gyrase inhibitor, against multidrug-resistant Neisseria gonorrhoeae isolates suggests a new effective option for oral treatment of gonorrhea.Antimicrob Agents Chemother.2014 Sep;58(9):5585-8. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.