Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00FGO
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| Former ID |
DAP000791
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| Drug Name |
Melphalan
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| Synonyms |
Alkeran; Levofalan; Levofolan; Levopholan; Melfalan; Melfalano; Melphalanum; Alanine Nitrogen Mustard; Phenylalanine mustard; Phenylalanine nitrogen mu stard; Phenylalanine nitrogen mustard; AY3360000; CB 3025; ALKERAN (TN); Alkeran (TN); At-290; CB-3025; L-PAM; L-Phenylalanine mustard; L-Sarcolysin; L-Sarcolysine; L-Sarkolysin; Melfalano [INN-Spanish]; Melphalanum [INN-Latin]; SK-15673; TRANSGENIC MODEL EVALUATION (MELPHALAN); MELPHALAN (SEE ALSO TRANSGENIC MODEL EVALUATION (MELPHALAN)); P-L-Sarcolysin; P-L-sarcolysine; TRANSGENIC LEP (MELPHALAN) (SEE ALSO MELPHALAN); Melphalan (JP15/USP/INN); Melphalan [USAN:INN:BAN:JAN]; P-Bis(beta-chloroethyl)aminophenylalanine; P-N-Di(chloroethyl)aminophenylalanine; P-N-di(chloroethyl)aminophenylala nine; P-Di-(2-chloroethyl)amino-L-phenylalanine; P-N-Bis(2-chloroethyl)amino-L-phenylalanine; L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine; L-3-(para-(Bis(2-chloroethyl)amino)phenyl)alanine; P-N,N-bis(2-chloroethyl)amino-L-phenylalanine; (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid; (2s)-2-amino-3-(4-[bis(2-chloroethyl)amino]phenyl)propanoic acid; 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine; 3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine; 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine; 4-(Bis(2-chloroethyl)amino)-L-phenylalanine; 4-[Bis(2-chloroethyl)amino]-L-phenylalanine; 4-[Bis-(2-chloroethyl)amino]-L-phenylalanine
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| Drug Type |
Small molecular drug
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| Indication | Multiple myeloma [ICD-11: 2A83; ICD-10: C90.0] | Approved | [1], [2] | |
| Intrahepatic cholangiocarcinoma [ICD-11: 2C12.10; ICD-10: C22.1; ICD-9: 155.1, 156.1] | Phase 3 | [3] | ||
| Therapeutic Class |
Anticancer Agents
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| Structure |
 |
Download2D MOL |
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| Formula |
C13H18Cl2N2O2
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| Canonical SMILES |
C1=CC(=CC=C1CC(C(=O)O)N)N(CCCl)CCCl
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| InChI |
1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1
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| InChIKey |
SGDBTWWWUNNDEQ-LBPRGKRZSA-N
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| CAS Number |
CAS 148-82-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9332, 611396, 7847435, 7979898, 8149411, 10303302, 10321915, 11335828, 11361067, 11363291, 11365853, 11368415, 11371727, 11374423, 11376577, 11462039, 11484023, 11487890, 11490500, 11492697, 11494211, 14874007, 14898602, 17389837, 24278538, 26611805, 26680129, 26752787, 46509130, 47588994, 47662283, 47736480, 47959741, 48413968, 48416205, 48423637, 48425272, 49831062, 49855032, 49865835, 50105436, 50989121, 53790153, 56463160, 57288513, 57288721, 57405528, 85789225, 91010646, 92307226
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| ChEBI ID |
CHEBI:28876
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| ADReCS Drug ID | BADD_D01376 ; BADD_D01377 | |||
| SuperDrug ATC ID |
L01AA03
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| SuperDrug CAS ID |
cas=000148823
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes indistinctus DSM22520
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -4.445; p = 0.001). | |||
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Studied Microbe: Bacteroides caccae ATCC 43185
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides caccae ATCC 43185 (log2FC = -4.295; p = 0.005). | |||
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Studied Microbe: Bacteroides cellulosilyticus DSM 14838
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -4.869; p = 0.001). | |||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -4.954; p = 0.002). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -5.52; p = 0.003). | |||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -4.571; p = 0.006). | |||
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Studied Microbe: Bacteroides finegoldii DSM17565
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides finegoldii DSM17565 (log2FC = -4.949; p = 0.008). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -5.753; p = 0.007). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -5.862; p = 0.003). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -5.808; p = 0.013). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -5.254; p = 0.005). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -4.345; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -3.492; p = 0.004). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -3.196; p = 0.005). | |||
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Studied Microbe: Bacteroides intestinalis DSM 17393
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -5.304; p = 0.002). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -5.235; p = 0.014). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -5.289; p = 0.005). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -4.233; p = 0.002). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -4.234; p = 0.006). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -4.383; p = 0.002). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -5.454; p = 0.003). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -5.412; p = 0.015). | |||
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Studied Microbe: Bacteroides WH2
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides WH2 (log2FC = -4.768; p = 0.008). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -5.301; p = 0.004). | |||
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Studied Microbe: Odoribacter splanchnicus
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Odoribacter splanchnicus (log2FC = -4.588; p = 0.007). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -5.47; p = 0.003). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -5.2; p = 0.004). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -5.155; p = 0.001). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Pretovella copri DSM 18205 (log2FC = -5.297; p = 0.003). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium adolescentis ATCC 15703
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bifidobacterium adolescentis ATCC 15703 (log2FC = -3.658; p = 0.003). | |||
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Studied Microbe: Bifidobacterium breve DSM 20213
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bifidobacterium breve DSM 20213 (log2FC = -4.704; p = 0.002). | |||
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Studied Microbe: Bifidobacterium longum subsp. Infantis CCUG52486
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bifidobacterium longum subsp. Infantis CCUG52486 (log2FC = -4.622; p = 0.006). | |||
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Studied Microbe: Bifidobacterium ruminantium
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bifidobacterium ruminantium (log2FC = -4.754; p = 0.005). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens ATCC25986
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Collinsella aerofaciens ATCC25986 (log2FC = -4.969; p = 0.006). | |||
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Studied Microbe: Collinsella intestinalis DSM 13280
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Collinsella intestinalis DSM 13280 (log2FC = -3.877; p = 0.004). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta ATCC 25559
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Eggerthella lenta ATCC 25559 (log2FC = -3.014; p = 0.004). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Edwardsiella tarda ATCC 23685
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Edwardsiella tarda ATCC 23685 (log2FC = -4.326; p = 0.002). | |||
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Studied Microbe: Enterobacter cancerogenus ATCC35316
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Enterobacter cancerogenus ATCC35316 (log2FC = -3.965; p = 0.005). | |||
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Studied Microbe: Escherichia coli BW25113
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Escherichia coli BW25113 (log2FC = -3.788; p = 0.003). | |||
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Studied Microbe: Proteus penneri ATCC 35198
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Proteus penneri ATCC 35198 (log2FC = -4.41; p = 0.005). | |||
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Studied Microbe: Providencia alcalifaciens DSM 30120
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Providencia alcalifaciens DSM 30120 (log2FC = -4.417; p = 0.003). | |||
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Studied Microbe: Providencia rettgeri DSM 1131
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Providencia rettgeri DSM 1131 (log2FC = -4.376; p = 0.004). | |||
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Studied Microbe: Providencia stuartii ATCC 25827
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Providencia stuartii ATCC 25827 (log2FC = -3.968; p = 0.01). | |||
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Studied Microbe: Salmonella typhimurium LT2
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Salmonella typhimurium LT2 (log2FC = -3.025; p = 0.005). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Clostridium ramosum DSM 1402
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Clostridium ramosum DSM 1402 (log2FC = -3.796; p = 0.003). | |||
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Studied Microbe: Clostridium spiroforme DSM1552
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Clostridium spiroforme DSM1552 (log2FC = -3.823; p = 0.004). | |||
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Studied Microbe: Eubacterium biforme DSM 3989
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -4.393; p = 0.002). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Anaerostipes sp.
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Anaerostipes sp. (log2FC = -4.127; p = 0.003). | |||
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Studied Microbe: Anaerotruncus colihominis DSM 17241
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Anaerotruncus colihominis DSM 17241 (log2FC = -4.376; p = 0.014). | |||
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Studied Microbe: Bacteroides pectinophilus ATCC 43243
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bacteroides pectinophilus ATCC 43243 (log2FC = -4.907; p = 0.003). | |||
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Studied Microbe: Blautia hansenii DSM20583
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Blautia hansenii DSM20583 (log2FC = -4.068; p = 0.004). | |||
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Studied Microbe: Blautia luti DSM 14534
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Blautia luti DSM 14534 (log2FC = -3.918; p = 0.005). | |||
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Studied Microbe: Bryantia formatexigens DSM 14469
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Bryantia formatexigens DSM 14469 (log2FC = -4.385; p = 0.01). | |||
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Studied Microbe: Clostridium asparagiforme DSM 15981
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Clostridium asparagiforme DSM 15981 (log2FC = -4.973; p = 0.012). | |||
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Studied Microbe: Clostridium difficile 120
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Clostridium difficile 120 (log2FC = -4.216; p = 0.004). | |||
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Studied Microbe: Clostridium hathewayi DSM 13479
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Clostridium hathewayi DSM 13479 (log2FC = -5.142; p = 0.009). | |||
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Studied Microbe: Clostridium scindens ATCC 35704
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Clostridium scindens ATCC 35704 (log2FC = -4.529; p = 0.004). | |||
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Studied Microbe: Clostridium sp.
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Clostridium sp. (log2FC = -3.955; p = 0.004). | |||
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Studied Microbe: Clostridium sporogenes ATCC 15579
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Clostridium sporogenes ATCC 15579 (log2FC = -4.074; p = 0.002). | |||
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Studied Microbe: Clostridium symbiosum ATCC 14940
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Clostridium symbiosum ATCC 14940 (log2FC = -4.488; p = 0.009). | |||
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Studied Microbe: Coprococcus comes ATCC 27758
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Coprococcus comes ATCC 27758 (log2FC = -4.711; p = 0.002). | |||
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Studied Microbe: Dorea formicigenerans ATCC 27755
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Dorea formicigenerans ATCC 27755 (log2FC = -4.147; p = 0.011). | |||
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Studied Microbe: Enterocloster bolteae ATCC BAA-613
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Enterocloster bolteae ATCC BAA-613 (log2FC = -4.657; p = 0.019). | |||
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Studied Microbe: Eubacterium hallii DSM3353
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Eubacterium hallii DSM3353 (log2FC = -4.726; p = 0.006). | |||
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Studied Microbe: Eubacterium rectale ATCC 33656
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Eubacterium rectale ATCC 33656 (log2FC = -3.734; p = 0.016). | |||
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Studied Microbe: Eubacterium ventriosum ATCC 27560
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Eubacterium ventriosum ATCC 27560 (log2FC = -4.673; p = 0.009). | |||
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Studied Microbe: Roseburia intestinalis L1-82
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Roseburia intestinalis L1-82 (log2FC = -3.905; p = 0.001). | |||
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Studied Microbe: Ruminococcus gnavus ATCC 29149
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Ruminococcus gnavus ATCC 29149 (log2FC = -3.441; p = 0.004). | |||
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Studied Microbe: Ruminococcus lactaris ATCC 29176
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Ruminococcus lactaris ATCC 29176 (log2FC = -4.432; p = 0.003). | |||
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Studied Microbe: Ruminococcus torques ATCC 27756
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Ruminococcus torques ATCC 27756 (log2FC = -4.618; p = 0.005). | |||
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Studied Microbe: Subdoligranulum variabile DSM 15176
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Subdoligranulum variabile DSM 15176 (log2FC = -3.71; p = 0.004). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Enterococcus faecalis V583
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Enterococcus faecalis V583 (log2FC = -3.528; p = 0.004). | |||
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Studied Microbe: Lactobacillus reuteri CF48-3A
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Lactobacillus reuteri CF48-3A (log2FC = -4.758; p = 0.004). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Tissierellales | ||||
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Studied Microbe: Anaerococcus hydrogenalis DSM 7454
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Anaerococcus hydrogenalis DSM 7454 (log2FC = -4.785; p = 0.008). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia muciniphila ATCC BAA-835
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Akkermansia muciniphila ATCC BAA-835 (log2FC = -4.645; p = 0.006). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
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Studied Microbe: Victivallis vadensis ATCC BAA-548
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Melphalan can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -2.95; p = 0.009). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human Deoxyribonucleic acid (hDNA) | Target Info | Modulator | [5] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7620). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 014691. | |||
| REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 4 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 5 | Alkylation of DNA by melphalan in relation to immunoassay of melphalan-DNA adducts: characterization of mono-alkylated and cross-linked products fr... Chem Biol Interact. 1990;73(2-3):183-94. | |||
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