Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00EZO
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| Former ID |
DIB012111
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| Drug Name |
TC-2216
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| Synonyms |
NNR Therapeutics; TC-5685; Nicotinic ACh modulators (schizophrenia), Targacept; Alpha-4 beta-2 neuronal nicotinic receptor (schizophrenia, depression), Targacept; Oral alpha-4/beta-2 neuronal nicotinic receptor stimulator (shizophrenia/depression), Targacept
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| Drug Type |
Small molecular drug
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| Indication | Mood disorder [ICD-11: 6A60-6E23] | Phase 1 | [1] | |
| Company |
Targacept
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| Structure |
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Download2D MOL |
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| Formula |
C12H17N3
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| Canonical SMILES |
C1CC2(CCN(C2)C3=CN=CC=C3)NC1
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| InChI |
1S/C12H17N3/c1-3-11(9-13-6-1)15-8-5-12(10-15)4-2-7-14-12/h1,3,6,9,14H,2,4-5,7-8,10H2
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| InChIKey |
NXIPMBQVNTWEEX-UHFFFAOYSA-N
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| CAS Number |
CAS 646055-67-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00583544) A Safety and Tolerability Single Ascending Dose Study in Healthy Volunteers. U.S. National Institutes of Health. | |||
| REF 2 | TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity.CNS Neurosci Ther.2008 Winter;14(4):266-77. | |||
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