Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00DIF
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| Former ID |
DIB019680
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| Drug Name |
CyPPA
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| Synonyms |
73029-73-9; N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine; CHEMBL453730; cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine; C16H23N5; N-cyclohexyl-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine; AC1LIR5Q; SCHEMBL3233745; GTPL2323; CTK8F8875; DTXSID20358676; USEMRPYUFJNFQN-UHFFFAOYSA-N; MolPort-000-762-862; ZINC492516; HMS3262M15; Tox21_500707; STK052676; MFCD01550586; BDBM50275157; CyPPA, >
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C16H23N5
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| Canonical SMILES |
CC1=CC(=NC(=N1)N2C(=CC(=N2)C)C)NC3CCCCC3
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| InChI |
1S/C16H23N5/c1-11-10-15(18-14-7-5-4-6-8-14)19-16(17-11)21-13(3)9-12(2)20-21/h9-10,14H,4-8H2,1-3H3,(H,17,18,19)
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| InChIKey |
USEMRPYUFJNFQN-UHFFFAOYSA-N
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| CAS Number |
CAS 73029-73-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
1159006, 4771447, 9195752, 25665763, 44509793, 46497387, 49699829, 50526756, 88258261, 90340684, 103647907, 104118715, 110085298, 121298541, 121361699, 135650151, 135698352, 162248103, 163133782, 163375797, 163563919, 163564661, 163838085, 166716506, 170558751, 175612513, 223532337, 229268723, 248514668, 249827909, 250201140, 252059710, 252156899, 252229796, 252425571, 252552971
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calcium-activated potassium channel KCa2.2 (KCNN2) | Target Info | Activator | [2] |
| Calcium-activated potassium channel KCa2.3 (KCNN3) | Target Info | Activator | [2] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2323). | |||
| REF 2 | Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br J Pharmacol. 2007 Jul;151(5):655-65. | |||
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