Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00CGU
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| Former ID |
DIB016755
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| Drug Name |
IMS
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| Synonyms |
INO-2002
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| Drug Type |
Small molecular drug
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| Indication | Inflammatory bowel disease [ICD-11: DD72; ICD-10: K50-K52] | Discontinued in Phase 1 | [1] | |
| Company |
Inotek Pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C4H10O3S
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| Canonical SMILES |
CC(C)OS(=O)(=O)C
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| InChI |
1S/C4H10O3S/c1-4(2)7-8(3,5)6/h4H,1-3H3
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| InChIKey |
SWWHCQCMVCPLEQ-UHFFFAOYSA-N
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| CAS Number |
CAS 926-06-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3156973, 8160197, 10538024, 12087892, 16032144, 17388959, 29281681, 48425228, 49856045, 56463732, 57328190, 77833456, 104332061, 124889893, 125231105, 125724835, 127345787, 127345788, 127802189, 129300358, 134980588, 135589224, 137166090, 142545981, 144208053, 151991835, 162156133, 162761131, 163692111, 164811379, 176330023, 180680441, 184577025, 188889164, 198935957, 204370645, 223517701, 223542392, 223685409, 223811048, 226668264, 241165764, 242060790, 242134460, 249833409, 249907497, 250183046, 250216645, 251877213, 252056096
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Inosine-5'-monophosphate dehydrogenase (IMPDH) | Target Info | Modulator | [2] |
| KEGG Pathway | Purine metabolism | |||
| Drug metabolism - other enzymes | ||||
| Metabolic pathways | ||||
| Pathwhiz Pathway | Purine Metabolism | |||
| Reactome | Purine ribonucleoside monophosphate biosynthesis | |||
| WikiPathways | Nucleotide Metabolism | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019853) | |||
| REF 2 | The novel inosine analogue INO-2002 exerts an anti-inflammatory effect in a murine model of acute lung injury. Shock. 2009 Sep;32(3):258-62. | |||
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