Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00CAO
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| Drug Name |
US9422240, 1-298
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| Synonyms |
SCHEMBL16761969; CHEMBL3899583; BDBM242556; US9422240, 1-298
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| Drug Type |
Small molecular drug
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H18F3N3O6
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| Canonical SMILES |
C1CN(C(=O)C(=C1O)C(=O)NCC(=O)O)CC2=CC=C(C=C2)OC3=NC=C(C=C3)C(F)(F)F
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| InChI |
1S/C21H18F3N3O6/c22-21(23,24)13-3-6-16(25-9-13)33-14-4-1-12(2-5-14)11-27-8-7-15(28)18(20(27)32)19(31)26-10-17(29)30/h1-6,9,28H,7-8,10-11H2,(H,26,31)(H,29,30)
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| InChIKey |
OAYSSFWXQZDVKQ-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HIF-prolyl hydroxylase 2 (HPH-2) | Target Info | Inhibitor | [1] |
| Target's Patent Info | HIF-prolyl hydroxylase 2 (HPH-2) | Target's Patent Info | [1] | |
| KEGG Pathway | HIF-1 signaling pathway | |||
| Pathways in cancer | ||||
| Renal cell carcinoma | ||||
| Panther Pathway | Hypoxia response via HIF activation | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Partially saturated nitrogen-containing heterocyclic compound. US9422240. | |||
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