Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00ASH
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| Former ID |
DNC000063
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| Drug Name |
3-methoxydesaminokynurenine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C12H15NO4
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| Canonical SMILES |
CC(CC(=O)C1=CC(=CC=C1)OC)(C(=O)O)N
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| InChI |
1S/C12H15NO4/c1-12(13,11(15)16)7-10(14)8-4-3-5-9(6-8)17-2/h3-6H,7,13H2,1-2H3,(H,15,16)
|
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| InChIKey |
WRBHWPHQKJOLHX-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Kynureninase (KYNU) | Target Info | Inhibitor | [1] |
| BioCyc | Superpathway of tryptophan utilization | |||
| Tryptophan degradation | ||||
| L-kynurenine degradation | ||||
| Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | ||||
| NAD de novo biosynthesis | ||||
| KEGG Pathway | Tryptophan metabolism | |||
| Metabolic pathways | ||||
| NetPath Pathway | TSLP Signaling Pathway | |||
| Pathwhiz Pathway | Tryptophan Metabolism | |||
| Reactome | Tryptophan catabolism | |||
| WikiPathways | Tryptophan metabolism | |||
| Metabolism of amino acids and derivatives | ||||
| NAD Biosynthesis II (from tryptophan) | ||||
| Selenium Micronutrient Network | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase. BMC Biochem. 2003 Sep 24;4:13. | |||
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