Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00APD
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| Former ID |
DNC005854
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| Drug Name |
3-(2-Dimethylamino-ethyl)-1H-indol-6-ol
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| Synonyms |
BRN 0160817; 6-Hydroxy-N,N-dimethyltryptamine; 1476-33-1; INDOL-6-OL, 3-(2-(DIMETHYLAMINO)ETHYL)-; CHEMBL382750; 3-(2-dimethylaminoethyl)-1H-indol-6-ol; 1H-Indol-6-ol, 3-[2-(dimethylamino)ethyl]-; 3-(2-Dimethylamino-ethyl)-1H-indol-6-ol; 5-22-12-00067 (Beilstein Handbook Reference); 6-hydroxy-N-dimethyltryptamine; AC1L257Q; DTXSID70163752; BDBM50171259; AKOS023092717; LS-83678
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C12H16N2O
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| Canonical SMILES |
CN(C)CCC1=CNC2=C1C=CC(=C2)O
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| InChI |
1S/C12H16N2O/c1-14(2)6-5-9-8-13-12-7-10(15)3-4-11(9)12/h3-4,7-8,13,15H,5-6H2,1-2H3
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| InChIKey |
WUQMRWPLIMXBDX-UHFFFAOYSA-N
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| CAS Number |
CAS 1476-33-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2A receptor (HTR2A) | Target Info | Inhibitor | [1] |
| 5-HT 2B receptor (HTR2B) | Target Info | Inhibitor | [1] | |
| 5-HT 2C receptor (HTR2C) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin Receptor 2 and STAT3 Signaling | |||
| Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
| SIDS Susceptibility Pathways | ||||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. | |||
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